| Scientifically,
it hasn't been proved to be hereditary. However, a familial clustering
of cases can be seen. Leukoderma means destruction of melanocytes by varied
mechanisms like burns, contact with acid, phenol or other chemicals.
Whereas vitiligo occurs due to unknown causes. Earliest case of Vitiligo
has occurred after the age of 4 years.
The Types of Vitiligo
There are two main types: Generalized and Localized.
Localized types occur only over one part of the body e.g. face, hands
or legs.
Generalized vitiligo involves more than 70% of the body surface area.
Segmental vitiligo is an interesting type of localized vitiligo where
patches occur along the direction of cutaneous nerves.
Vitiligo Treatment
Vitiligo
is treated with drugs known as Psoralens. Psoralens have to interact with
UVA rays of light to be beneficial in vitiligo. This treatment of Psoralens
with UVA is known as PUVA Therapy. The source of UVA rays can be from
the sun or from special tube lights which emit UVA spectrum of light.
However, the treatment is of very long duration and many a times unsatisfactory.
Mostly patches on the bones, lips and tips of the fingers refuse to respond.
New Advances in Treatment
Nowadays new dermato-surgical modalities of treatment
are available. Herein, normal pigmented skin can be grafted onto a patch
of vitiligo by several surgical methods.
Such methods are :
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Punch grafting
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Thin Theirsha's or split skin grafts.
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Postage stamp grafts.
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Tattooing with medical grade sterile inherit pigments.
Melasma
Pregnancy Mark
Melasma is also known as chloasma. The word melasma
actually means "the mask of pregnancy". It is the discoloration of skin
on the face or on another part of the body in both the sexes. Melasma
is a darkening of the facial skin, often affecting the outer cheeks and
areas above the mouth. The pigment producing cells in our body called
melanocytes, are stimulated to produce extra pigment leading to this discoloration.
Factors that influence this production include estrogen supplements, birth
control pills, pregnancy, cell hypersensitivity to normal estrogen levels
and sun exposure.
Treatment of Melasma
Treatment involves lightening the discoloration through
bleaching and protection from the sun. Hydroquinone is the active agent
in skin bleaches. Bleaches don't know the difference between normal and
abnormal skin tone, so you need to apply the bleach only to the abnormal
skin. Bleaches are usually applied twice daily. Some bleaches contain
their own sunscreens.
Depending upon how dark the area is compared to the normal skin tone,
it can take as along as one year or sometimes longer. If there seems to
be some darkening after the application of bleaches, discontinue use of
that agent and check with a dermatologist. Glycolic acid is a wonderful
base to apply prior to the bleach as it helps draw the bleach into the
skin better. Glycolic acid peels can be helpful as well. A series of approximately
6 weekly peels can help expedite the bleaching process. Some patients
have turned to laser therapy for treatment. When you have achieved your
desired results, stop your bleach but continue your sun protection. You
may even want to continue your glycolic acid and Vitamin A creams. The
other important issue is protection from the sun. You absolutely must
wear a sunscreen with an SPF of 30 to 45 with UVA and UVB protection,
wear a hat etc, and minimize your sun exposure.
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