| There are three second-generation drugs: glipizide
, glyburide, and glimepiride. These drugs are generally taken one to two
times a day, before meals. All sulfonylurea drugs have similar effects
on blood sugar levels, but they differ in side effects, how often they
are taken, and interactions with other drugs.
2. Metformin is a biguanide. It lowers blood sugar by
helping insulin work better, mostly in the liver. It is usually taken
two times a day. A side effect of metformin may be diarrhea, but this
is improved when the drug is taken with food
Insulin shots:
Insulin helps your cells take in blood sugar. You then
no longer have too much sugar in your blood. Your doctor will try you
on pills first. But sometimes pills don’t work. Or they work at first
and then stop. When this happens, your doctor may have you take both pills
and insulin or maybe just insulin alone. Your doctor will tell you what
kind of insulin to take, how much and when.
More on Insulin: There are four types of insulin, based
on
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Time of onset of action
-
Peak time of action
-
Duration of action
However, each person responds to insulin in his or her
own way. That is why onset, peak time, and duration are given as ranges.
Rapid-acting insulin reaches the blood within 15 minutes after injection.
It peaks 30 to 90 minutes later and may last as long as 5 hours. Short-acting
(regular) insulin usually reaches the blood within 30 minutes after injection.
It peaks 2 to 4 hours later and stays in the blood for about 4 to 8 hours.
Intermediate-acting (NPH and lente) insulins reach the blood 2 to 6 hours
after injection. They peak 4 to 14 hours later and stay in the blood for
about 14 to 20 hours.
Long-acting (ultralente) insulin takes 6 to 14 hours
to start working. It has no peak or a very small peak 10 to 16 hours after
injection. It stays in the blood between 20 and 24 hours. Some insulins
come mixed together. For example, you can buy regular and NPH insulins
already mixed in one bottle. They make it easier to inject two kinds of
insulin at the same time. However, you can’t adjust the amount of one
insulin without also changing how much you get of the other insulin.
All insulins have added ingredients to keep them fresh and help them work
better. Intermediate- and long-acting insulins also have ingredients to
make them act longer. Today’s insulins are very pure. Allergic reactions
are rare.
Tips for taking Insulin :
Using cold insulin can make your shot more painful.
You can keep the bottle of insulin you are currently using at room temperature
or warm the bottle by gently rolling it between your hands before you
fill the syringe. If you buy more than one bottle of insulin at a time,
store the extra bottles in the refrigerator until you start to use them.
Never store insulin at very cold (under 4 degrees Celsius) or very hot
(over 40 degrees Celsius) temperatures. Extreme temperatures destroy insulin.
Do not put your insulin in the freezer or in direct sunlight. Insulin
may lose some potency if the bottle has been opened for more than 30 days.
Look at the bottle closely to make sure the insulin looks normal. If you
use regular, it should be perfectly clear—no floating pieces or color.
If you use NPH or lente, it should be cloudy, with no floating pieces
or crystals on the bottle. Do not use insulin past the expiration date.
Treatment and Prevention of Nephropathy
Strict blood glucose control may delay progression of
kidney disease and other diabetic related complications in type 2 diabetics
as well as type 1.
Control of existing high blood pressure is extremely important not only
for heart disease stroke and heart failure but also for preventing progression
to kidney failure. ACE inhibitors beneficial effect kidneys and delay
the progression of kidney failure
Treatment of Neuropathy
Tricyclic antidepressant amitriptyline commonly used
for neuropathy pain. The anti-seizure drug gabapentin may be an effective
alternative to amitriptyline. If foot pain, numbness or tingling is worse
at night, diphenhydramine (Benadryl) may help. Delayed stomach emptying
caused by neuropathy may be relieved by erythromycin or metoclopramide.
Treatment and Prevention of Retinopathy
Tight insulin control is also proving to help prevent
retinopathy in patients with either type 1 or 2 diabetes. Once damage
to the eye develops, eye surgery may be needed. Argon or diode laser photocoagulation
is proving to be particularly effective in reducing severe visual loss
from retinopathy.
Prevention of Infections
Everyone with diabetes who is at risk for complications
should have annual influenza vaccination and a vaccination against pneumococcal
pneumonia.
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