| What exactly goes wrong in Psoriasis is that the
epidermal cells multiply about 4 times more rapidly within patches of
Psoriasis as compared to the normal skin. Unfortunately the factors that
trigger off this hyper-proliferation are yet unknown. Today the current
concept is that this defect could be due to an exaggerated immunological
response and inflammation against some common organisms like bacteria
and viruses. Psoriasis is neither hereditary nor contagious.
Types of Psoriasis
Exfoliate Psoriasis
It is a type where there are widespread lesions involving
more than 80% of the body surface. This is associated with fever and weakness
and can leave the patient ill for months together.
Pustule Psoriasis
It is the most dangerous type, where the whole skin
is filled with pustules which come together to form lakes of pus. The
patient has high grade fever and is bedridden. Rarely this can be fatal
too.
Psoriatic Arthropathy
Rarely the joints can become painful and stiff due
to Psoriasis. This problem usually occurs in patients of long standing
disease.
Treatment of Psoriasis
The treatment is tailor-made for each patient. Localized
forms can be treated with creams and ointments. Commonly used creams are
steroid creams, diathronal creams, coal tar ointment, liquid paraffin
and even plain Vaseline ointment. However, in generalized varieties, systemic
treatment is chosen. Drugs like Methotrexte, Azathioprine, Hydroxyurea
are anti-metabolites, which are commonly used. However, these drugs are
quite toxic and cannot be taken without specialist's supervision. PUVA
therapy using psoralins and UVA rays is also one modality of treatment
which is commonly used.
Even the most recent and the costliest drugs do not guarantee a complete
cure. All drugs can induce a remission but psoriasis may flare up under
unknown influences. Relapse of psoriasis is known to occur in winters
and under psychologically stressful conditions.
Recent Drugs for Psoriasis
Retinoids and Calcipotriol are the most recent introductions
in treatment. However the costs of these drugs are exorbitant in India.
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