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Hepatitis C

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Introduction
Hepatitis C is a disease of the liver caused by the Hepatitis C virus.

Clinical Features of Hepatitis C
  • Jaundice.
  • Fatigue.
  • Abdominal pain.
  • Loss of appetite.
  • Intermittent nausea.
  • Vomiting.
Etiological Agent
  • Hepatitis C virus (HCV).
Transmission of Hepatitis C
  • Primarily blood borne, also sexual and perinatal.
Risk Groups
  • Injecting drug users.
  • Hemodialysis patients.
  • Health care workers.
  • Sex contacts of infected persons.
  • Persons with multiple sex partners.
  • Infants born to infected women have evidence of liver disease (e.g., persistently abnormal ALT levels).
Prevention of Hepatitis C
  • Screening of blood/organ/tissue donors.
  • Counseling to reduce/modify high–risk practices.
Treatment of Hepatitis C
  • Drugs are licensed for the treatment of persons with chronic Hepatitis C.
  • Treatment is effective in 10 to 40% of persons.
Sequelae
  • Chronic infection >85% of infected persons.
  • Chronic liver disease: 70% of infected persons.
  • Deaths from chronic liver disease: 8,000 to 10,000/yr.
  • Leading indication for liver transplantation.

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Hepatitis

  • Difference between Hepatitis A & B
  • Hepatitis E
  • Hepatitis C
  • Hepatitis B
  • Hepatitis A

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