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  • Plastic Valve To Ease Circulatory Problems

Plastic Valve To Ease Circulatory Problems

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Times of India
20 March 2012
By Mirror Bureau
If heart valves don’t close properly, they are replaced. But venous valve failure is always treated with drugs. A new implant is now set to change that with an ingenious design

It’s one of the most commonly occurring medical conditions — chronic venous in–sufficiency (CVI). Millions of people from around the world suffer from weak veins that require treatment, with twice as many women being affected as men.

The cause of this widespread condition is restricted functioning of the venous valves in the legs. If the venous valve is no longer able to close properly, blood will observe the laws of gravity in between heartbeats and flow down to collect in the legs.

Plastic Valve To Ease Circulatory Problems

This leads to edemas, and can cause open ulcers in particularly severe cases. CVI is usually treated with anti–inflammatory drugs and diuretics; as yet there is no globally available venous valve implant that can be used to treat the illness.

This is something that researchers from the Fraunhofer Institute for Manufacturing Engineering and Automation IPA in Germany are setting out to change: In close collaboration with four industrial partners they have developed an automated production facility that can make venous valve prostheses from polycarbonate–urethane (PCU), a plastic.

Presicion 3d printing

The centerpiece of the facility is a 3D droplet dispensing tool which enables the researchers to precisely apply a particular polymer onto freeform surfaces and at the same time combine various grades of polymer hardness, called Shore hardnesses.

“3D droplet dispensing technology is an additive procedure that allows three–dimensional geometries to be created layer by layer using a polymer”, explains Oliver Schwarz, group manager at the IPA.

The scientists use PCU because it is particularly strong and flexible, while another useful property of the material is that it is easy to sew into surrounding tissue.

PCU structures can be made in very thin layers, which is ideal when replacing wafer–thin atrioventricular valves.

“By using PCU in combination
with our 3D dispensing kinematics, we can achieve
seamless transitions
within the material between six different grades of elasticity and hardness — without any breaking points whatsoever.

This technique mirrors the design of highly stressed structures in nature. It can’t be done using injection molding”, says Schwarz.

How the valve is made

Initially, the polymers are dissolved in a solvent and deposited onto a venous valve prosthetic mold one droplet at a time, using the dispensing tool. The system is accurate to within 25 micrometers, and can deliver up to 100 droplets per second, each with a volume of 2 to 60 nanolitres. A six–axis system positions the feeder precisely above the mold.

Once it is fully coated with droplets, the mold is bathed in a warm stream of nitrogen. This causes the solvent to evaporate, leaving the polymer behind. Further layers are applied by repeating the dispensing process, and in the end the polymer prosthesis can simply be peeled from the mold.

Doctors can take the finished replacement valves and implant them into the veins of the leg via a catheter passed through the skin.

The finished highly durable venous valve is seen here on top of a finger

Disclaimer: The news story on this page is the copyright of the cited publication. This has been reproduced here for visitors to review, comment on and discuss. This is in keeping with the principle of ‘Fair dealing’ or ‘Fair use’. Visitors may click on the publication name, in the news story, to visit the original article as it appears on the publication’s website.

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