Research
Due to the global rise of type 2 diabetes in youth, it is imperative to determine, through investigation, the following:
- Population–based prevalence rates for type 2 diabetes in young people.
- Cost–to–benefit ratios of screening for diabetes and pre–diabetes conditions (including metabolic syndrome).
- Methods for classification of diabetes in young people.
- The natural history of type 2 diabetes in children, particularly with regards to co–morbidities and complications.
- The safety and efficacy of therapeutic drugs.
- Prevention strategies – both primary and secondary.
References
1. Kitagawa T, Owada M, Urakami T, et al. Increased incidence of non–insulin dependent diabetes mellitus among Japanese schoolchildren correlates with an increased intake of animal protein and fat. Clin Pediatr (Phila) 1998, 37: 111–5.
2. Chuang LM, Sung FC, Lee CY, et al. Incidence and prevalence of childhood diabetes in Taiwan – an experience with nation–wide screening [abstract]. Diabetes Res Clin Pract 2002, 56: S16.
3. Harris SB, Gittelsohn J, Hanley A, et al. The prevalence of NIDDM and associated risk factors in native Canadians. Diabetes Care 1997, 20: 185–7.
4. Braun B, Zimmermann MB, Kretchmer N, et al. Risk factors for diabetes and cardiovascular disease in young Australian aborigines. A 5–year follow–up study. Diabetes Care 1996, 19: 472–9.
5. SEARCH for Diabetes in Youth Study Group. The burden of diabetes mellitus among US youth: prevalence estimates from the SEARCH for Diabetes in Youth Study. Pediatrics 2006, 118, 1510–8.
6. Yokoyama H, Okudaira M, Otani T, et al. Higher incidence of diabetic nephropathy in type 2 than type 1 diabetes in early–onset diabetes in Japan. Kidney Int 2000, 58: 302–11.
7. Krakoff J, Lindsay RS, Looker HC, et al. Incidence of retinopathy and nephropathy in youth–onset compared with adult–onset type 2 diabetes. Diabetes Care 2003, 26: 76–81.
8. Dean HJ, Flett B. Natural history of type 2 diabetes diagnosed in childhood long term follow–up in young adult years [abstract]. Diabetes 2002, 51: A24.
9. Eppens MC, Craig ME, Cusumano J, et al. Prevalence of diabetes complications in adolescents with type 2 compared with type 1 diabetes. Diabetes Care 2006, 29: 1300–6.
Source: International Diabetes Federation
